Genetic Obesity Syndromes
نویسندگان
چکیده
S.F.A. Grant (ed.), The Genetics of Obesity, DOI 10.1007/978-1-4614-8642-8_2, © Springer Science+Business Media New York 2014 Abstract A number of genetic obesity syndromes have been identifi ed by sequencing candidate genes in patients with severe obesity. Many of the initial fi ndings emerged from studying families who displayed a classical Mendelian pattern of inheritance; however, with more comprehensive genome wide approaches, increasingly more complex models of inheritance are likely to emerge. The functional and physiological characterization of the human obesity syndromes has provided information that has diagnostic value (Fig. 2.1), has led to specifi c treatments in some patients and continues to provide insights into the mechanisms involved in the regulation of body weight in humans.
منابع مشابه
A Case of Bardet-Biedl Syndrome
Etemadi K1, Khazaii MR2 1. MSC of Human Genetic, Molecular Medicine and Genetic department, Medical school, Hamadan University of medical sciences. 2. Assistant professor of Pediatric Urology Abstract Background: The Bardet Biedl syndrome is a heterogenous and autosomal recessive disorder. Primary features are: retinitis pigmentosa, obesity, polydactyly, mental retardation, renal abnorm...
متن کاملMonogenic human obesity syndromes.
Over the past decade, we have witnessed a major increase in the scale of scientific activity devoted to the study of energy balance and obesity. This explosion of interest has, to a large extent, been driven by the identification of genes responsible for murine obesity syndromes and the novel physiological pathways revealed by those genetic discoveries. We and others recently have identified se...
متن کاملMOMO Syndrome with Holoprosencephaly and Cryptorchidism: Expanding the Spectrum of the New Obesity Syndrome
There are multiple genetic disorders with known or unknown etiology grouped under obesity syndromes. Inspite of having multisystem involvement and often having a characteristic presentation, the understanding of the genetic causes in the majority of these syndromes is still lacking. The common obesity syndromes are Bardet-Biedl, Prader-Willi, Alstrom, Albright's hereditary osteodystrophy, Carpe...
متن کاملPWS and Obesity, and PWS look-alikes
Obesity is a common finding in our general population, the proportion of obese individuals having increased at an alarming rate all over the world in the past 20 years. Compared to growth failure, obesity is rare in a population of individuals with a genetic syndrome. One database for genetic syndromes, Online Mendelian Inheritance in Man, contains 169 matches for obesity and 421 matches for gr...
متن کاملGenetics of obesity and overgrowth syndromes.
Childhood overweight and obesity is highly prevalent within society. In the majority of individuals, weight gain is the result of exposure to an 'obesogenic' environment, superimposed on a background of genetic susceptibility brought about by evolutionary adaptation. These individuals tend to be tall in childhood with a normal final adult height, as opposed to those who have an underlying monog...
متن کامل